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Issue 20, 2019
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Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

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Abstract

Elastin-like peptides are biopolymers that display LCST behaviour in solution quite similar to other synthetic polymers like polyethylene oxide. Here we study the structure of the peptide GVG(VPGVG)3 in a temperature range of 25 °C to 70 °C with small angle neutron scattering. The LCST for this peptide is outside the experimental range of temperatures. Molecular conformation is well described within the model of a random coil but increasing temperature leads to significant changes. The peptide displays a combination of conformational change and aggregation that show up in the scattering at low and intermediate scattering vector q. The aggregate size is determined from an integral measure of the scattered intensity. It increases with temperature and concentration. For low concentration we find a size variation with temperature that may be related to the collapse of conformation at the inverse temperature transition (ITT).

Graphical abstract: Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

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Publication details

The article was received on 22 Mar 2019, accepted on 28 Apr 2019 and first published on 30 Apr 2019


Article type: Paper
DOI: 10.1039/C9SM00583H
Soft Matter, 2019,15, 4192-4199

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    Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

    A. Matt, B. Kuttich, I. Grillo, S. Weißheit, C. M. Thiele and B. Stühn, Soft Matter, 2019, 15, 4192
    DOI: 10.1039/C9SM00583H

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