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Issue 20, 2019
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Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

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Abstract

Elastin-like peptides are biopolymers that display LCST behaviour in solution quite similar to other synthetic polymers like polyethylene oxide. Here we study the structure of the peptide GVG(VPGVG)3 in a temperature range of 25 °C to 70 °C with small angle neutron scattering. The LCST for this peptide is outside the experimental range of temperatures. Molecular conformation is well described within the model of a random coil but increasing temperature leads to significant changes. The peptide displays a combination of conformational change and aggregation that show up in the scattering at low and intermediate scattering vector q. The aggregate size is determined from an integral measure of the scattered intensity. It increases with temperature and concentration. For low concentration we find a size variation with temperature that may be related to the collapse of conformation at the inverse temperature transition (ITT).

Graphical abstract: Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

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Supplementary files

Article information


Submitted
22 Mar 2019
Accepted
28 Apr 2019
First published
30 Apr 2019

Soft Matter, 2019,15, 4192-4199
Article type
Paper

Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG)3

A. Matt, B. Kuttich, I. Grillo, S. Weißheit, C. M. Thiele and B. Stühn, Soft Matter, 2019, 15, 4192
DOI: 10.1039/C9SM00583H

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