Jump to main content
Jump to site search

Issue 8, 2019
Previous Article Next Article

Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

Author affiliations

Abstract

Oxygen vacancy (OV) engineering in semiconductors can greatly enhance the separation of photo-induced electron–hole pairs, thereby enhancing the photocatalytic activity. Taking inspiration from this, we prepared a novel BiOBr–H/Rub2d composite by functionalizing OV-rich BiOBr (named BiOBr–H) with a carboxyl functionalized ruthenium photosensitizer (Ru(bpy)2C-pyCl2, abbreviated as Rub2d), which was then successfully applied for photodynamic therapy (PDT). Density functional theory (DFT) calculations confirmed efficient electron transfer from the Rub2d complex to the intermediate energy level of BiOBr–H under visible light irradiation. In vitro and in vivo studies demonstrated that BiOBr–H/Rub2d was a superior agent for photodynamic therapy compared with the free ruthenium complex. The theoretical and experimental data presented thus reveal for the first time that abundant OVs in BiOBr–H can significantly improve the photocatalytic activity of a photosensitizer, resulting in the generation of more reactive oxygen species to enhance PDT. The findings of this study thus offer a new strategy for the development of highly efficient cancer therapies.

Graphical abstract: Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Nov 2018, accepted on 20 Dec 2018 and first published on 20 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC05275A
Chem. Sci., 2019,10, 2336-2341
  • Open access: Creative Commons BY license
  •   Request permissions

    Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

    S. Guan, L. Wang, S. Xu, D. Yang, G. I. N. Waterhouse, X. Qu and S. Zhou, Chem. Sci., 2019, 10, 2336
    DOI: 10.1039/C8SC05275A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements