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Issue 20, 2019
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Crystal-facet-dependent denitrosylation: modulation of NO release from S-nitrosothiols by Cu2O polymorphs

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Abstract

Nitric oxide (NO), a gaseous small molecule generated by the nitric oxide synthase (NOS) enzymes, plays key roles in signal transduction. The thiol groups present in many proteins and small molecules undergo nitrosylation to form the corresponding S-nitrosothiols. The release of NO from S-nitrosothiols is a key strategy to maintain the NO levels in biological systems. However, the controlled release of NO from the nitrosylated compounds at physiological pH remains a challenge. In this paper, we describe the synthesis and NO releasing ability of Cu2O nanomaterials and provide the first experimental evidence that the nanocrystals having different crystal facets within the same crystal system exhibit different activities toward S-nitrosothiols. We used various imaging techniques and time-dependent spectroscopic measurements to understand the nature of catalytically active species involved in the surface reactions. The denitrosylation reactions by Cu2O can be carried out multiple times without affecting the catalytic activity.

Graphical abstract: Crystal-facet-dependent denitrosylation: modulation of NO release from S-nitrosothiols by Cu2O polymorphs

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Supplementary files

Article information


Submitted
20 Mar 2019
Accepted
24 Apr 2019
First published
24 Apr 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 5308-5318
Article type
Edge Article

Crystal-facet-dependent denitrosylation: modulation of NO release from S-nitrosothiols by Cu2O polymorphs

S. Ghosh, P. Roy, S. Prasad and G. Mugesh, Chem. Sci., 2019, 10, 5308
DOI: 10.1039/C9SC01374A

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