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Issue 18, 2019
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Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics

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Abstract

Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.

Graphical abstract: Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics

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Publication details

The article was received on 20 Jan 2019, accepted on 01 Apr 2019 and first published on 02 Apr 2019


Article type: Edge Article
DOI: 10.1039/C9SC00324J
Chem. Sci., 2019,10, 4847-4853
  • Open access: Creative Commons BY license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics

    G. Lu, C. Lv, W. Bao, F. Li, F. Zhang, L. Zhang, S. Wang, X. Gao, D. Zhao, W. Wei and H. Xie, Chem. Sci., 2019, 10, 4847
    DOI: 10.1039/C9SC00324J

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