Jump to main content
Jump to site search

Issue 7, 2019
Previous Article Next Article

Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Author affiliations

Abstract

Some ruthenium–hydride complexes react with O2 to yield H2O2, therefore the principle of microscopic reversibility dictates that the reverse reaction is also possible, that H2O2 could transfer an H to a Ru complex. Mechanistic evidence is presented, using the Ru-catalyzed ABTS˙ reduction reaction as a probe, which suggests that a Ru–H intermediate is formed via deinsertion of O2 from H2O2 following coordination to Ru. This demonstration that H2O2 can function as an H donor and reductant under biologically-relevant conditions provides the proof-of-concept that H2O2 may function as a reductant in living systems, ranging from metalloenzyme-catalyzed reactions to cellular redox homeostasis, and that H2O2 may be viable as an environmentally-friendly reductant and H source in green catalysis.

Graphical abstract: Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Back to tab navigation

Supplementary files

Article information


Submitted
05 Dec 2018
Accepted
07 Dec 2018
First published
14 Dec 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 2025-2033
Article type
Edge Article

Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Y. Htet, Z. Lu, S. A. Trauger and A. G. Tennyson, Chem. Sci., 2019, 10, 2025
DOI: 10.1039/C8SC05418E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements