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Issue 10, 2019
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Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry

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Abstract

A solid-supported cyanoborohydride cartridge was designed to facilitate the automated production of positron emission tomography (PET) radiotracers synthesised via reductive amination chemistry. Two compounds, N-(4-fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine ([18F]2) and 1,3,4,6-tetra-O-acetyl-2-(4-fluorobenzylamine)-2-deoxy-β-D-glucopyranose ([18F]4) were radiosynthesised efficiently using a GE FASTlab™ platform, obtained in >98% RCP in a total synthesis time of 75 min (from the start of synthesis) with RCY (non-decay corrected) of 7.5 ± 2.5% and 6.0 ± 1.1%, respectively. The cartridge method provides a convenient alternative to conventional powdered reducing agents typically used in reductive amination radiochemistry.

Graphical abstract: Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry

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Supplementary files

Article information


Submitted
05 Jun 2019
Accepted
25 Jul 2019
First published
25 Jul 2019

React. Chem. Eng., 2019,4, 1748-1751
Article type
Communication

Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry

L. Allott, C. Barnes, D. Brickute, S. F. J. Leung and E. O. Aboagye, React. Chem. Eng., 2019, 4, 1748
DOI: 10.1039/C9RE00226J

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