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Issue 9, 2019
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Definitive screening designs for multistep kinetic models in flow

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Currently, rate-based understanding of organic reactions employed in the manufacture of active pharmaceutical ingredients (APIs) is often not obtained. In many cases, the generation of kinetic models is still seen as a specialised and time intensive activity, which can only be justified at certain instances in development. In this Communication, we report the application of a definitive screening design (DSD) in combination with reaction profiling for the efficient collection of kinetic data. The experimental data (10 profiles, 40 experimental data points) were collected within a short time frame (<1 week) within a continuous flow reactor. The data were fitted to a multistep kinetic model consisting of 3 fitted rate constants and 3 fitted activation energies. The approach is demonstrated on a Friedel–Crafts type reaction used in the synthesis of an important API. Our approach enables early identification of the sensitivity of product quality to parameter changes and the early use of process models to identify optimal process-equipment combinations in silico, significantly reducing development time and scale-up risks.

Graphical abstract: Definitive screening designs for multistep kinetic models in flow

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Supplementary files

Article information

03 May 2019
06 Jun 2019
First published
06 Jun 2019

React. Chem. Eng., 2019,4, 1565-1570
Article type

Definitive screening designs for multistep kinetic models in flow

C. A. Hone, A. Boyd, A. O'Kearney-McMullan, R. A. Bourne and F. L. Muller, React. Chem. Eng., 2019, 4, 1565
DOI: 10.1039/C9RE00180H

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