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Issue 9, 2019
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Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

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Abstract

Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h−1.

Graphical abstract: Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

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Supplementary files

Article information


Submitted
24 Feb 2019
Accepted
08 Apr 2019
First published
08 Apr 2019

This article is Open Access

React. Chem. Eng., 2019,4, 1571-1578
Article type
Paper

Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

P. Sagmeister, J. D. Williams, C. A. Hone and C. O. Kappe, React. Chem. Eng., 2019, 4, 1571
DOI: 10.1039/C9RE00087A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry.

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