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Issue 71, 2019
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Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

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Abstract

Various mechanisms of different designs have emerged for the purpose of microparticle separation and cell sorting. The main goals behind such designs are to create high throughput and high purity sample isolation. In this study, high efficiency, high throughput and precise separation of microparticles under inertial lift and drag forces induced by trapezoidal curvilinear channels are reported. This work is the first to focus and recover 2 from 5 μm and 2 from 10 μm particles in spiral channels in a sheath-less flow device, which reduces the overall complexity of the system and allows for higher throughput. The new microfluidic chip design is fabricated in glass using femtosecond laser ablation. In addition, mathematical force calculations were conducted during the design phase of the microfluidic channels and compared with experiments. The results show a close prediction of the equilibrium position of the tested microparticles.

Graphical abstract: Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

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Supplementary files

Article information


Submitted
30 Jul 2019
Accepted
28 Nov 2019
First published
18 Dec 2019

This article is Open Access

RSC Adv., 2019,9, 41970-41976
Article type
Paper

Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

A. Al-Halhouli, A. Albagdady and A. Dietzel, RSC Adv., 2019, 9, 41970
DOI: 10.1039/C9RA05916D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry.

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