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Issue 33, 2019
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Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

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Abstract

Degradable low-fouling hydrogels are ideal vehicles for drug and cell delivery. For each application, hydrogel degradation rate must be re-optimized for maximum therapeutic benefit. We developed a method to rapidly and predictably tune degradation rates of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) (P(EG)xMA) hydrogels by modifying two interdependent variables: (1) base-catalysed crosslink degradation kinetics, dependent on crosslinker electronics (electron withdrawing groups (EWGs)); and, (2) polymer hydration, dependent on the molecular weight (MW) of poly(ethylene glycol) (PEG) pendant groups. By controlling PEG MW and EWG strength, P(EG)xMA hydrogels were tuned to degrade over 6 to 52 d. A 6-member P(EG)xMA copolymer library yielded slow and fast degrading low-fouling hydrogels suitable for short- and long-term delivery applications. The degradation mechanism was also applied to RGD-functionalized poly(carboxybetaine methacrylamide) (PCBMAA) hydrogels to achieve slow (∼50 d) and fast (∼13 d) degrading low-fouling, bioactive hydrogels.

Graphical abstract: Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

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Publication details

The article was received on 08 May 2019, accepted on 10 Jun 2019 and first published on 17 Jun 2019


Article type: Paper
DOI: 10.1039/C9RA03441B
RSC Adv., 2019,9, 18978-18988
  • Open access: Creative Commons BY-NC license
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    Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

    Muhammad M. Shoaib, V. Huynh, Y. Shad, R. Ahmed, A. H. Jesmer, G. Melacini and R. G. Wylie, RSC Adv., 2019, 9, 18978
    DOI: 10.1039/C9RA03441B

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