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Issue 65, 2019, Issue in Progress
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Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction

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Abstract

The Suzuki–Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki–Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Graphical abstract: Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction

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Supplementary files

Article information


Submitted
03 Sep 2019
Accepted
29 Oct 2019
First published
20 Nov 2019

This article is Open Access

RSC Adv., 2019,9, 37818-37824
Article type
Paper

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction

A. Czompa, B. L. Pásztor, J. A. Sahar, Z. Mucsi, D. Bogdán, K. Ludányi, Z. Varga and I. M. Mándity, RSC Adv., 2019, 9, 37818
DOI: 10.1039/C9RA07044C

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