Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 59, 2019
Previous Article Next Article

Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Author affiliations

Abstract

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed complementary biological profiles and new lead compounds with sub-micromolar activities against each pathogen and high selectivities when compared to mammalian cell lines.

Graphical abstract: Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Back to tab navigation

Supplementary files

Article information


Submitted
15 Aug 2019
Accepted
07 Oct 2019
First published
23 Oct 2019

This article is Open Access

RSC Adv., 2019,9, 34227-34234
Article type
Paper

Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

N. B. Agyemang, C. R. Kukla, T. C. Edwards, Q. Li, M. K. Langen, A. Schaal, A. D. Franson, A. G. Casals, K. A. Donald, A. J. Yu, M. J. Donlin, L. A. Morrison, J. E. Tavis and R. P. Murelli, RSC Adv., 2019, 9, 34227
DOI: 10.1039/C9RA06383H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements