Issue 54, 2019
From the journal:

RSC Advances

Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts†

Yuuki Wada,a   Akira Matsumoto, ORCID logo ‡a   Keisuke Asano ORCID logo *a  and  Seijiro Matsubara ORCID logo *a  

* Corresponding authors

a Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan
E-mail: asano.keisuke.5w@kyoto-u.ac.jp, matsubara.seijiro.2e@kyoto-u.ac.jp
Fax: +81 75 383 2438
Tel: +81 75 383 7571

Abstract

Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities.

Graphical abstract: Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

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Article information

DOI
https://doi.org/10.1039/C9RA05532K
Article type
Paper
Submitted
18 Jul 2019
Accepted
30 Sep 2019
First published
04 Oct 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 31654-31658

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Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Y. Wada, A. Matsumoto, K. Asano and S. Matsubara, RSC Adv., 2019, 9, 31654 DOI: 10.1039/C9RA05532K

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