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Issue 32, 2019
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Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes

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Abstract

Iron(III)- and cobalt(III)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four meso positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by Pseudomonas aeruginosa. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor.

Graphical abstract: Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes

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Publication details

The article was received on 16 Apr 2019, accepted on 23 May 2019 and first published on 13 Jun 2019


Article type: Paper
DOI: 10.1039/C9RA02872B
RSC Adv., 2019,9, 18697-18702
  • Open access: Creative Commons BY-NC license
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    Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes

    E. Sakakibara, Y. Shisaka, H. Onoda, D. Koga, N. Xu, T. Ono, Y. Hisaeda, H. Sugimoto, Y. Shiro, Y. Watanabe and O. Shoji, RSC Adv., 2019, 9, 18697
    DOI: 10.1039/C9RA02872B

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