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Issue 24, 2019
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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

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Abstract

AZB-IMC2 was developed as a COX-2 specific probe that exhibited a brighter fluorescence signal in cancer cells that overexpress COX-2 compared to normal cells. Oxidative stress agent-treated inflamed cell lines inducing high COX-2 levels revealed an enhanced fluorescence signal. Inhibitory studies showed a markedly reduced fluorescence intensity in cancer cells. The results suggested that AZB-IMC2 could be developed as a promising molecular tool for imaging guiding during surgery.

Graphical abstract: Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

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Supplementary files

Article information


Submitted
14 Mar 2019
Accepted
26 Apr 2019
First published
30 Apr 2019

This article is Open Access

RSC Adv., 2019,9, 13372-13377
Article type
Paper

Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

T. Pewklang, K. Chansaenpak, R. Lai, P. Noisa and A. Kamkaew, RSC Adv., 2019, 9, 13372
DOI: 10.1039/C9RA01948K

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