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Issue 15, 2019
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Synthesis and characterisation of α-carboxynitrobenzyl photocaged L-aspartates for applications in time-resolved structural biology

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Abstract

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged L-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14).

Graphical abstract: Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

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Publication details

The article was received on 05 Feb 2019, accepted on 06 Mar 2019 and first published on 15 Mar 2019


Article type: Paper
DOI: 10.1039/C9RA00968J
RSC Adv., 2019,9, 8695-8699
  • Open access: Creative Commons BY-NC license
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    Synthesis and characterisation of α-carboxynitrobenzyl photocaged L-aspartates for applications in time-resolved structural biology

    J. J. Zaitsev-Doyle, A. Puchert, Y. Pfeifer, H. Yan, B. A. Yorke, H. M. Müller-Werkmeister, C. Uetrecht, J. Rehbein, N. Huse, A. R. Pearson and M. Sans, RSC Adv., 2019, 9, 8695
    DOI: 10.1039/C9RA00968J

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