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Issue 10, 2019, Issue in Progress
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Determination of sialic acid in serum samples by dispersive solid-phase extraction based on boronate-affinity magnetic hollow molecularly imprinted polymer sorbent

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Abstract

Boronate-affinity magnetic hollow molecularly imprinted polymers (B-MhMIPs) were prepared with sialic acid (SA) as the template, 3-aminophenylboronic acid (APBA) as the functional monomer and glycidilmethacrylate (GMA) as the co-monomer to chemisorb Fe3O4 nanoparticles. Furthermore, the hollow structure made the nanoparticles have more binding sites at both internal and external surfaces, which can facilitate the removal of template molecules from polymers and enhance the adsorption abilities towards SA. After optimizing, the adsorption pH was controlled at 4.0, and this was different from most cis-diol-containing compounds. Under the optimal conditions, the limit of detection for SA was 0.025 μg mL−1 (n = 3). This method was applied to analyze serum samples with different spiked levels, and the recoveries of the SA were in the range of 70.9–106.2%. These results confirmed the superiority of the B-MhMIPs for selective and efficient enrichment of trace SA from complex matrices.

Graphical abstract: Determination of sialic acid in serum samples by dispersive solid-phase extraction based on boronate-affinity magnetic hollow molecularly imprinted polymer sorbent

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Supplementary files

Article information


Submitted
21 Jan 2019
Accepted
04 Feb 2019
First published
12 Feb 2019

This article is Open Access

RSC Adv., 2019,9, 5394-5401
Article type
Paper

Determination of sialic acid in serum samples by dispersive solid-phase extraction based on boronate-affinity magnetic hollow molecularly imprinted polymer sorbent

W. Huang, X. Hou, Y. Tong and M. Tian, RSC Adv., 2019, 9, 5394
DOI: 10.1039/C9RA00511K

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