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Issue 3, 2019, Issue in Progress
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Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

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Abstract

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

Graphical abstract: Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

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Supplementary files

Article information


Submitted
06 Dec 2018
Accepted
19 Dec 2018
First published
11 Jan 2019

This article is Open Access

RSC Adv., 2019,9, 1536-1540
Article type
Paper

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

S. A. Rzhevskiy, A. A. Ageshina, G. A. Chesnokov, P. S. Gribanov, M. A. Topchiy, M. S. Nechaev and A. F. Asachenko, RSC Adv., 2019, 9, 1536
DOI: 10.1039/C8RA10040C

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