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Issue 4, 2019
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Microfluidic assisted synthesis of PLGA drug delivery systems

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Abstract

Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible and biodegradable polymer that recently attracted attention for use as part of drug delivery systems (DDS). In this context, there is an emerging need for a rapid, reliable and reproducible method of synthesis. Here, microfluidic systems provide great opportunities for synthesizing carriers in a tightly controlled manner and with low consumption of materials, energy and time. These miniature devices have been the focus of recent research since they can address the challenges inherent to the bulk system, e.g. low drug loading efficiency and encapsulation, broad size distribution and burst initial release. In this article, we provide an overview of current microfluidic systems used in drug delivery production, with a special focus on PLGA-based DDS. In this context, we highlight the advantages associated with the use of microchip systems in the fabrication of nanoparticles (NPs) and microparticles (MPs), e.g. in achieving complex morphologies. Furthermore, we discuss the challenges for selecting proper microfluidics for targeted DDS production in a translational setting and introduce strategies that are used to overcome microfluidics shortcomings, like low throughput for production.

Graphical abstract: Microfluidic assisted synthesis of PLGA drug delivery systems

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Article information


Submitted
30 Oct 2018
Accepted
16 Dec 2018
First published
15 Jan 2019

This article is Open Access

RSC Adv., 2019,9, 2055-2072
Article type
Review Article

Microfluidic assisted synthesis of PLGA drug delivery systems

S. Rezvantalab and M. Keshavarz Moraveji, RSC Adv., 2019, 9, 2055
DOI: 10.1039/C8RA08972H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

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