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Issue 10, 2019
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Palladium-catalyzed dearomative arylphosphorylation of indoles

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Abstract

A palladium-catalyzed dearomative arylphosphorylation reaction of indoles involving C–C/C–P bond formation is developed. Through the intramolecular dearomative carbopalladation of indoles followed by an intermolecular benzyl–Pd termination with dialkylphosphite, a range of unique indolines bearing vicinal tetrasubstituted and phosphate-containing trisubstituted stereocenters are obtained in good yields. Synthetic transformations of the product show practical utilities of the reaction.

Graphical abstract: Palladium-catalyzed dearomative arylphosphorylation of indoles

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Publication details

The article was received on 15 Feb 2019, accepted on 23 Mar 2019 and first published on 27 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00246D
Org. Chem. Front., 2019,6, 1577-1580

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    Palladium-catalyzed dearomative arylphosphorylation of indoles

    J. Weng, L. Xing, W. Hou, R. Liang and Y. Jia, Org. Chem. Front., 2019, 6, 1577
    DOI: 10.1039/C9QO00246D

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