Solvent-tuned chemoselective carboazidation and diazidation of alkenes via iron catalysis

Abstract

We have described Fe-catalyzed chemoselective oxidative carboazidation and diazidation of alkenes by employing CH₂Cl₂ as the chloromethyl source and TMSN₃ as the azido source. For the synthesis, we have taken the advantage of solvent-controlled generation of C-based and N-based radicals, allowing the construction of molecularly diverse azido compounds from readily available starting materials through a simple operation.