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Issue 5, 2019
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Hypersonic poration of supported lipid bilayers

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Hypersound (ultrasound of gigahertz (GHz) frequency) has been recently introduced as a new type of membrane-disruption method for cells, vesicles and supported lipid bilayers (SLBs), with the potential to improve the efficiency of drug and gene delivery for biomedical applications. Here, we fabricated an integrated microchip, composed of a nano-electromechanical system (NEMS) resonator and a gold electrode as the extended gate of a field effect transistor (EGFET), to study the effects of hypersonic poration on an SLB in real time. The current recordings revealed that hypersound enabled ion conduction through the SLB by inducing transient nanopores in the membrane, which act as the equivalent of ion channels and show gating behavior. The mechanism of pore formation was studied by cyclic voltammetry (CV), atomic force microscopy (AFM) and laser scanning microscopy (LSM), which support the causality between hypersound-triggered deformation and the reversible membrane disruption of the SLB. This finding contributes to the development of an approach to reversibly control membrane permeability by hypersound.

Graphical abstract: Hypersonic poration of supported lipid bilayers

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The article was received on 16 Nov 2018, accepted on 09 Jan 2019 and first published on 14 Jan 2019

Article type: Research Article
DOI: 10.1039/C8QM00589C
Mater. Chem. Front., 2019,3, 782-790

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    Hypersonic poration of supported lipid bilayers

    Y. Lu, J. Huskens, W. Pang and X. Duan, Mater. Chem. Front., 2019, 3, 782
    DOI: 10.1039/C8QM00589C

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