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Issue 4, 2019
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Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications

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Abstract

The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy. Herein, we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands, and delineate their photoluminescence and X-ray excited optical luminescence (XEOL) properties. These cluster complexes, namely [{Re6Q8}(PPh2CH2CH2COO)6]4− (Q = S (1); Se, (2)), have the least cytotoxicity among all the tested hexanuclear metal-clusters, are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.

Graphical abstract: Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications

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Supplementary files

Article information


Submitted
09 Nov 2018
Accepted
09 Jan 2019
First published
10 Jan 2019

Inorg. Chem. Front., 2019,6, 882-892
Article type
Research Article

Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications

A. A. Ivanov, D. I. Konovalov, T. N. Pozmogova, A. O. Solovieva, A. R. Melnikov, K. A. Brylev, N. V. Kuratieva, V. V. Yanshole, K. Kirakci, K. Lang, S. N. Cheltygmasheva, N. Kitamura, L. V. Shestopalova, Y. V. Mironov and M. A. Shestopalov, Inorg. Chem. Front., 2019, 6, 882
DOI: 10.1039/C8QI01216D

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