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Monodisperse, sequence-defined macromolecules as a tool to evaluate the limits of ring-closing metathesis

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Abstract

Sequence-defined macromolecules of uniform size unlock the door to many new applications in polymer chemistry, such as structure/property or structure/activity relationship investigations, which cannot be conducted accurately, if the investigated macromolecules exhibit dispersity. We herein demonstrate a first example by reporting the efficient and template-free synthesis of monodisperse, sequence-defined cyclic oligomers that are significantly larger than conventional large macrocycles (here >150 backbone atoms). Linear monodisperse precursors were utilized to evaluate the limits of ring-closing metathesis (RCM), manifesting clear trends depending on the ring size and introduced side chains. Furthermore, this work is the first example of a sequence-defined synthesis of a polymer architecture other than linear macromolecules.

Graphical abstract: Monodisperse, sequence-defined macromolecules as a tool to evaluate the limits of ring-closing metathesis

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Publication details

The article was received on 22 Mar 2019, accepted on 22 Apr 2019 and first published on 30 Apr 2019


Article type: Paper
DOI: 10.1039/C9PY00438F
Polym. Chem., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Monodisperse, sequence-defined macromolecules as a tool to evaluate the limits of ring-closing metathesis

    K. S. Wetzel and M. A. R. Meier, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C9PY00438F

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