Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 2, 2019
Previous Article Next Article

In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

Author affiliations

Abstract

The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.

Graphical abstract: In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

Back to tab navigation

Supplementary files

Article information


Submitted
13 Sep 2018
Accepted
09 Jan 2019
First published
11 Jan 2019

Photochem. Photobiol. Sci., 2019,18, 495-504
Article type
Paper

In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

S. Callaghan, M. A. Filatov, H. Savoie, R. W. Boyle and M. O. Senge, Photochem. Photobiol. Sci., 2019, 18, 495
DOI: 10.1039/C8PP00402A

Social activity

Search articles by author

Spotlight

Advertisements