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Issue 46, 2019
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Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

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Abstract

A water-soluble pillar[5]arene, decafunctionalized with thioether and carboxylate fragments, was synthesized as a structural analogue of Sugammadex. Its ability to restore the contraction of the diaphragm muscle by encapsulating the muscle relaxant rocuronium bromide was demonstrated. Using UV-vis, NMR and fluorescence spectroscopy, it was shown that the muscle relaxant is associated with the pillar[5]arene with an association constant of 4500 M−1 and a stoichiometry of 1 : 1. The structure of the inclusion complex of the pillar[5]arene with rocuronium bromide was additionally investigated by quantum chemical methods.

Graphical abstract: Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

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Supplementary files

Article information


Submitted
12 Oct 2019
Accepted
07 Nov 2019
First published
07 Nov 2019

Org. Biomol. Chem., 2019,17, 9951-9959
Article type
Paper

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

D. N. Shurpik, O. A. Mostovaya, D. A. Sevastyanov, O. A. Lenina, A. S. Sapunova, A. D. Voloshina, K. A. Petrov, I. V. Kovyazina, P. J. Cragg and I. I. Stoikov, Org. Biomol. Chem., 2019, 17, 9951
DOI: 10.1039/C9OB02215E

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