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Issue 40, 2019
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A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

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Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.

Graphical abstract: A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

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Article information


Submitted
07 Sep 2019
Accepted
25 Sep 2019
First published
25 Sep 2019

Org. Biomol. Chem., 2019,17, 8982-8986
Article type
Communication

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

K. Lauder, D. Masci, A. Toscani, A. Al Mekdad, G. W. Black, N. L. Brown, N. J. Turner, R. Luisi and D. Castagnolo, Org. Biomol. Chem., 2019, 17, 8982
DOI: 10.1039/C9OB01962F

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