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Issue 12, 2019
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Asymmetric total synthesis of (+)-asenapine

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Asymmetric total synthesis of (+)-asenapine, an atypical antipsychotic drug, used for treating schizophrenia and acute mania associated with bipolar disorder, is reported. The key steps are the organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization.

Graphical abstract: Asymmetric total synthesis of (+)-asenapine

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23 Jan 2019
26 Feb 2019
First published
26 Feb 2019

Org. Biomol. Chem., 2019,17, 3225-3231
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Asymmetric total synthesis of (+)-asenapine

P. Szcześniak, O. Staszewska-Krajewska and J. Mlynarski, Org. Biomol. Chem., 2019, 17, 3225
DOI: 10.1039/C9OB00178F

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