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Issue 6, 2019
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An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide

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Abstract

Hydrogen sulfide (H2S), a critical endogenous signaling molecule, is widely involved in many physiological processes. Endoplasmic reticulum, an important organelle with a sac-like structure, plays crucial roles in maintaining the normal function of cells. Accordingly, monitoring the H2S levels in endoplasmic reticulum is of great importance. Herein, we have developed an endoplasmic reticulum-targetable fluorescent probe, ER-CN, for H2S detection. ER-CN features excellent sensing properties, such as high sensitivity and selectivity. In addition, ER-CN exhibits low cytotoxicity and a fine endoplasmic reticulum targeting property (with a Pearson's colocalization coefficient of 0.95). Significantly, visualization of H2S in the endoplasmic reticulum of living HeLa cells by using ER-CN was successfully realized.

Graphical abstract: An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide

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Publication details

The article was received on 02 Dec 2018, accepted on 16 Jan 2019 and first published on 16 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB02998A
Org. Biomol. Chem., 2019,17, 1436-1441

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    An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide

    H. Zhang, J. Chen, H. Xiong, Y. Zhang, W. Chen, J. Sheng and X. Song, Org. Biomol. Chem., 2019, 17, 1436
    DOI: 10.1039/C8OB02998A

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