Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 28, 2019
Previous Article Next Article

Probing Ca2+-induced conformational change of calmodulin with gold nanoparticle-decorated single-walled carbon nanotube field-effect transistors

Author affiliations

Abstract

Nanomaterials are ideal for electrochemical biosensors, with their nanoscale dimensions enabling the sensitive probing of biomolecular interactions. In this study, we compare field-effect transistors (FET) comprised of unsorted (un-) and semiconducting-enriched (sc-) single-walled carbon nanotubes (SWCNTs). un-SWCNTs have both metallic and semiconducting SWCNTs in the ensemble, while sc-SWCNTs have a >99.9% purity of semiconducting nanotubes. Both SWCNT FET devices were decorated with gold nanoparticles (AuNPs) and were then employed in investigating the Ca2+-induced conformational change of calmodulin (CaM) – a vital process in calcium signal transduction in the human body. Different biosensing behavior was observed from FET characteristics of the two types of SWCNTs, with sc-SWCNT FET devices displaying better sensing performance with a dynamic range from 10−15 M to 10−13 M Ca2+, and a lower limit of detection at 10−15 M Ca2+.

Graphical abstract: Probing Ca2+-induced conformational change of calmodulin with gold nanoparticle-decorated single-walled carbon nanotube field-effect transistors

Back to tab navigation

Supplementary files

Article information


Submitted
11 Apr 2019
Accepted
29 Jun 2019
First published
01 Jul 2019

Nanoscale, 2019,11, 13397-13406
Article type
Paper
Author version available

Probing Ca2+-induced conformational change of calmodulin with gold nanoparticle-decorated single-walled carbon nanotube field-effect transistors

W. Shao, S. C. Burkert, D. L. White, V. L. Scott, J. Ding, Z. Li, J. Ouyang, F. Lapointe, P. R. L. Malenfant, K. Islam and A. Star, Nanoscale, 2019, 11, 13397
DOI: 10.1039/C9NR03132D

Social activity

Search articles by author

Spotlight

Advertisements