Jump to main content
Jump to site search

Issue 13, 2019
Previous Article Next Article

Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma

Author affiliations

Abstract

Multimodality therapy under imaging-guidance is significant to improve the accuracy of cancer treatment. In this study, a photoacoustic imaging (PAI)-guided anticancer strategy based on poly-L-lysine functionalized melanin nanoparticles (MNP-PLL) was developed to treat laryngeal squamous cell carcinoma (LSCC). As a promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA nanoparticles were combined with photothermal ablation against primary tumors and miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor cells. Furthermore, taking advantage of the photoacoustic properties of melanin, PAI guided therapy could optimize the time point of NIR irradiation to maximize the efficacy of photothermal therapy (PTT). The in vitro and in vivo results proved that the combined treatments displayed the most significant tumor suppression compared with monotherapy. By integrating thermo-gene therapies into a theranostic nanoplatform, the MNP-PLL/miR-145-5p nanoparticles significantly suppressed the LSCC progression, indicating their great potential use for cancer therapy.

Graphical abstract: Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma

Back to tab navigation

Supplementary files

Article information


Submitted
03 Feb 2019
Accepted
25 Feb 2019
First published
01 Mar 2019

Nanoscale, 2019,11, 6285-6296
Article type
Paper

Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma

B. Fan, X. Yang, X. Li, S. Lv, H. Zhang, J. Sun, L. Li, L. Wang, B. Qu, X. Peng and R. Zhang, Nanoscale, 2019, 11, 6285
DOI: 10.1039/C9NR01122F

Social activity

Search articles by author

Spotlight

Advertisements