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Issue 19, 2019
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Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

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Abstract

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.

Graphical abstract: Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

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Article information


Submitted
01 Feb 2019
Accepted
19 Apr 2019
First published
22 Apr 2019

Nanoscale, 2019,11, 9756-9759
Article type
Paper

Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

J. Alliot, I. Theodorou, D. Nguyen, C. Forier, F. Ducongé, E. Gravel and E. Doris, Nanoscale, 2019, 11, 9756
DOI: 10.1039/C9NR01068H

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