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Issue 19, 2019
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Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

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Abstract

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.

Graphical abstract: Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

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Publication details

The article was received on 01 Feb 2019, accepted on 19 Apr 2019 and first published on 22 Apr 2019


Article type: Paper
DOI: 10.1039/C9NR01068H
Nanoscale, 2019,11, 9756-9759

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    Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

    J. Alliot, I. Theodorou, D. Nguyen, C. Forier, F. Ducongé, E. Gravel and E. Doris, Nanoscale, 2019, 11, 9756
    DOI: 10.1039/C9NR01068H

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