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Issue 15, 2019
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Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

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Abstract

A dedicated nanofiber design for applications in the biomedical domain is based on the understanding of nanofiber structures. The structure of electrospun nanofibers strongly influences their properties and functionalities. In polymeric nanofibers X-ray scattering and diffraction methods, i.e. SAXS and WAXD, are capable of decoding their structural insights from about 100 nm down to the Angström scale. Here, we present a comprehensive X-ray scattering and diffraction based study and introduce new data analysis approaches to unveil detailed structural features in electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDFhfp) nanofiber membranes. Particular emphasis was placed on anisotropic morphologies being developed during the nanofiber fabrication process. Global analysis was performed on SAXS data to derive the nanofibrillar structure of repeating lamella crystalline domains with average dimensions of 12.5 nm thickness and 7.8 nm spacing along with associated tie-molecules. The varying surface roughness of the nanofiber was evaluated by extracting the Porod exponent in parallel and perpendicular direction to the nanofiber axis, which was further validated by Atomic Force Microscopy. Additionally, the presence of a mixture of the monoclinic alpha and the orthorhombic beta PVDFhfp phases both exhibiting about 6% larger unit cells compared to the corresponding pure PVDF phases was derived from WAXD. The current study shows a generic approach in detailed understanding of internal structures and surface morphology for nanofibers. This forms the basis for targeted structure and morphology steering and the respective controlling during the fabrication process with the aim to engineer nanofibers for different biomedical applications with specific requirements.

Graphical abstract: Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

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Publication details

The article was received on 15 Jan 2019, accepted on 18 Mar 2019 and first published on 19 Mar 2019


Article type: Paper
DOI: 10.1039/C9NR00446G
Nanoscale, 2019,11, 7176-7187

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    Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

    A. K. Maurya, L. Weidenbacher, F. Spano, G. Fortunato, R. M. Rossi, M. Frenz, A. Dommann, A. Neels and A. Sadeghpour, Nanoscale, 2019, 11, 7176
    DOI: 10.1039/C9NR00446G

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