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Issue 11, 2019
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Measurement of nanomechanical properties of DNA molecules by PeakForce atomic force microscopy based on DNA origami

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Abstract

Characterization of the stiffness of thin DNA strands remains difficult. By constructing bilayer DNA molecules, we investigated their mechanical properties using AFM. Increased DNA thickness through DNA origami greatly reduced the substrate effect when measuring Young's modulus, thus providing a more accurate picture of the inherent nanomechanical properties of DNA.

Graphical abstract: Measurement of nanomechanical properties of DNA molecules by PeakForce atomic force microscopy based on DNA origami

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Publication details

The article was received on 22 Dec 2018, accepted on 19 Feb 2019 and first published on 20 Feb 2019


Article type: Communication
DOI: 10.1039/C8NR10354B
Nanoscale, 2019,11, 4707-4711

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    Measurement of nanomechanical properties of DNA molecules by PeakForce atomic force microscopy based on DNA origami

    L. Li, P. Zhang, J. Li, Y. Wang, Y. Wei, J. Hu, X. Zhou, B. Xu and B. Li, Nanoscale, 2019, 11, 4707
    DOI: 10.1039/C8NR10354B

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