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En route to terpene natural products utilizing supramolecular cyclase mimetics

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Abstract

Covering: literature up to 2018

Terpenes are a class of natural products characterized by remarkable structural diversity. Much of this diversity arises biosynthetically from a handful of linear precursors through the so-called tail-to-head terpene cyclization reaction. This reaction is one of the most complex observed in nature, and historically attempts to replicate it with non-enzymatic means have met with little success. In recent years, however, the development of manmade binding pockets that allow such reactions to take place has been reported. This Highlight provides an overview of this nascent field, and outlines the challenges that need to be overcome moving forward.

Graphical abstract: En route to terpene natural products utilizing supramolecular cyclase mimetics

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Publication details

The article was received on 23 Jan 2019 and first published on 25 Apr 2019


Article type: Highlight
DOI: 10.1039/C9NP00003H
Nat. Prod. Rep., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    En route to terpene natural products utilizing supramolecular cyclase mimetics

    Q. Zhang, L. Catti, L. Syntrivanis and K. Tiefenbacher, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C9NP00003H

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