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Issue 5, 2019
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The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

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Abstract

Covering: 2000 to 2018

Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the “pericyclases,” are the subject of this review.

Graphical abstract: The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

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Article information


Submitted
19 Aug 2018
First published
12 Oct 2018

Nat. Prod. Rep., 2019,36, 698-713
Article type
Review Article
Author version available

The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

C. S. Jamieson, M. Ohashi, F. Liu, Y. Tang and K. N. Houk, Nat. Prod. Rep., 2019, 36, 698
DOI: 10.1039/C8NP00075A

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