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Issue 47, 2019
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Synthesis, characterization and photodynamic activity of Sn(iv) triarylcorroles with red-shifted Q bands

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Abstract

Two Sn(IV) triarylcorroles were synthesised and characterized. The absorption spectrum of a meso-thien-2-yl substituted tin(IV)corrole (1-Sn) is red shifted compared to its phenyl analogue (2-Sn) and shows no sign of aggregation in solution. 1-Sn and 2-Sn exhibited singlet oxygen quantum yields of 0.87 and 0.54 in DMF, and have a triplet lifetime of 31 and 50 μs, respectively. Time dependent cellular uptake in MCF-7 cells for 1-Sn reached a peak at 24 h, and 1-Sn was found to be more lipophilic than 2-Sn. 1-Sn showed good photo-cytotoxicity on exposure to a Thorlabs 625 nm LED with an IC50 value of 3.2 μM and remained inactive in the dark.

Graphical abstract: Synthesis, characterization and photodynamic activity of Sn(iv) triarylcorroles with red-shifted Q bands

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Publication details

The article was received on 29 Jun 2019, accepted on 04 Nov 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9NJ03391B
New J. Chem., 2019,43, 18805-18812

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    Synthesis, characterization and photodynamic activity of Sn(IV) triarylcorroles with red-shifted Q bands

    B. Babu, E. Prinsloo, J. Mack and T. Nyokong, New J. Chem., 2019, 43, 18805
    DOI: 10.1039/C9NJ03391B

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