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Issue 22, 2019
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A red-emissive mitochondrial probe for imaging of the viscosity in living cells

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Abstract

A novel water-soluble fluorescent probe L based on indole salts has been designed, synthesized and fully characterized. The systematic investigations demonstrated that probe L shows red emission and the fluorescence intensity is linear with the viscosity of the medium. Probe L is able to selectively accumulate in mitochondria within 1 min without any additional reagents for membrane permeabilization. It has been used to distinguish the viscosity differences between mitochondria in normal and nystatin-treated HeLa cells. In addition, due to the good photostability, probe L can be used to monitor the dynamics of mitochondria. These results support that probe L might provide a promising approach for the fluorescence detection of mitochondrial viscosity in living biological systems.

Graphical abstract: A red-emissive mitochondrial probe for imaging of the viscosity in living cells

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Publication details

The article was received on 10 Apr 2019, accepted on 08 May 2019 and first published on 08 May 2019


Article type: Paper
DOI: 10.1039/C9NJ01826C
New J. Chem., 2019,43, 8811-8815

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    A red-emissive mitochondrial probe for imaging of the viscosity in living cells

    H. Wang, F. Cai, L. Zhou, J. He, D. Feng, Y. Wei, Z. Feng, X. Gu, U. Kajsa and Z. Hu, New J. Chem., 2019, 43, 8811
    DOI: 10.1039/C9NJ01826C

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