Jump to main content
Jump to site search

Issue 9, 2019
Previous Article Next Article

High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

Author affiliations

Abstract

There is a need for biofunctionalised magnetic nanoparticles for many biomedical applications, including MRI contrast agents that have a range of surface properties and functional groups. A library of eleven adducts, each formed by condensing a reducing sugar with a catechol hydrazide, for nanoparticle functionalisation has been created using a high-throughput chemical synthesis methodology. The enzymatic transformation of an N-acetylglucosamine (GlcNAc) adduct into an N-acetyllactosamine adduct by β-1,4-galactosyltransferase illustrates how chemoenzymatic methods could provide adducts bearing complex and expensive glycans. Superparamagnetic iron oxide nanoparticles (8 nm diameter, characterised by TEM, DLS and SQUID) were coated with these adducts and the magnetic resonance imaging (MRI) properties of GlcNAc-labelled nanoparticles were determined. This straightforward approach can produce a range of MRI contrast agents with a variety of biofunctionalised surfaces.

Graphical abstract: High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

Back to tab navigation

Supplementary files

Article information


Submitted
14 Jun 2019
Accepted
29 Jul 2019
First published
29 Jul 2019

This article is Open Access

Nanoscale Adv., 2019,1, 3597-3606
Article type
Paper

High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

Thomas W. Fallows, A. J. McGrath, J. Silva, S. G. McAdams, A. Marchesi, F. Tuna, S. L. Flitsch, R. D. Tilley and S. J. Webb, Nanoscale Adv., 2019, 1, 3597
DOI: 10.1039/C9NA00376B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements