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Issue 2, 2019

Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion

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Abstract

We report the specific and sensitive detection of microRNA using an inverse DNA-mediated liposome fusion assay. This assay is homogeneous, and does not require washing, separation, or enzyme-associated amplification steps. By fine-tuning the surface functionalisation of the liposomes, liposome concentration, and assay temperature, we demonstrated a sub-nanomolar limit of detection for the target.

Graphical abstract: Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion

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Article information


Submitted
08 Nov 2018
Accepted
14 Nov 2018
First published
21 Nov 2018

This article is Open Access

Nanoscale Adv., 2019,1, 532-536
Article type
Communication

Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion

C. Jumeaux, E. Kim, P. D. Howes, H. Kim, R. Chandrawati and M. M. Stevens, Nanoscale Adv., 2019, 1, 532 DOI: 10.1039/C8NA00331A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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