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Issue 7, 2019
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Unexpected therapeutic effects of cisplatin

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Abstract

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.

Graphical abstract: Unexpected therapeutic effects of cisplatin

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Publication details

The article was received on 06 Mar 2019, accepted on 30 Apr 2019 and first published on 30 Apr 2019


Article type: Critical Review
DOI: 10.1039/C9MT00049F
Metallomics, 2019,11, 1182-1199

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    Unexpected therapeutic effects of cisplatin

    M. Raudenska, J. Balvan, M. Fojtu, J. Gumulec and M. Masarik, Metallomics, 2019, 11, 1182
    DOI: 10.1039/C9MT00049F

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