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Issue 3, 2019
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Isatin and its derivatives: a survey of recent syntheses, reactions, and applications

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Abstract

Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of research work has been done regarding the synthesis, chemical properties, and biological and industrial applications of isatin. In this review, we have reported several novel methods for the synthesis of N-, C2-, and C3-substituted and spiro derivatives of isatin. The isatin moiety also shows important chemical reactions such as oxidation, ring expansion, Friedel–Crafts reaction and aldol condensation. These reactions, in turn, produce several biologically viable compounds like 2-oxindoles, tryptanthrin, indirubins, and many more. We have also summarized some recently reported biological activities exhibited by isatin derivatives, like anti-cancer, anti-bacterial, anti-diabetic and others. Special attention has been paid to their anti-cancer activity, and various anti-cancer targets such as histone deacetylase, carbonic anhydrase, tyrosine kinase, and tubulin have been discussed in detail. Other applications of isatin derivatives, such as in the dye industry and in corrosion prevention, have also been discussed.

Graphical abstract: Isatin and its derivatives: a survey of recent syntheses, reactions, and applications

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Publication details

The article was received on 28 Nov 2018, accepted on 15 Jan 2019 and first published on 15 Jan 2019


Article type: Review Article
DOI: 10.1039/C8MD00585K
Med. Chem. Commun., 2019,10, 351-368

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    Isatin and its derivatives: a survey of recent syntheses, reactions, and applications

    Varun, Sonam and R. Kakkar, Med. Chem. Commun., 2019, 10, 351
    DOI: 10.1039/C8MD00585K

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