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Issue 13, 2019
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Rational design of a high-throughput droplet sorter

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Abstract

The high-throughput selection of individual droplets is an essential function in droplet-based microfluidics. Fluorescence-activated droplet sorting is achieved using electric fields triggered at rates up to 30 kHz, providing the ultra-high throughput relevant in applications where large libraries of compounds or cells must be analyzed. To achieve such sorting frequencies, electrodes have to create an electric field distribution that generates maximal actuating forces on the droplet while limiting the induced droplet deformation and avoid disintegration. We propose a metric characterizing the performance of an electrode design relative to the theoretical optimum and analyze existing devices using full 3D simulations of the electric fields. By combining parameter optimization with numerical simulation we derive rational design guidelines and propose optimized electrode configurations. When tested experimentally, the optimized design show significantly better performance than the standard designs.

Graphical abstract: Rational design of a high-throughput droplet sorter

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Supplementary files

Article information


Submitted
13 Feb 2019
Accepted
06 Apr 2019
First published
03 Jun 2019

This article is Open Access

Lab Chip, 2019,19, 2220-2232
Article type
Paper

Rational design of a high-throughput droplet sorter

S. S. Schütz, T. Beneyton, J. Baret and T. M. Schneider, Lab Chip, 2019, 19, 2220
DOI: 10.1039/C9LC00149B

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    [Original citation] - Published by The Royal Society of Chemistry.

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