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Passive, non-pharmacological sweat collection and analysis using a skin-interfaced, soft microfluidic system with colorimetric biomarker assays relevant to kidney disorders

Abstract

The rich range of biomarkers in sweat and the ability to collect sweat in a non-invasive manner create interest in this biofluid for assessments of health and physiological status, with potential applications that range from sports and fitness to clinical medicine. This paper introduces two important advances in recently reported classes of soft, skin-interfaced microfluidic systems for sweat capture and analysis: (1) a simple, broadly applicable means for collection of sweat that bypasses requirements for physical/mental exertion or pharmacological stimulation and (2) a set of enzymatic chemistries and colorimetric readout approaches for determining the concentrations of creatinine and urea in sweat, across physiologically relevant ranges. The results allow for routine, non-pharmacological capture of sweat across patient populations, such as infants and the elderly, that cannot be expected to sweat through exercise, and they create potential opportunities in the use of sweat for kidney disease screening/monitoring. Studies on human subjects demonstrate these essential capabilities, with quantitative comparisons to standard methods. The results expand the range of options available in microfluidic sampling and sensing of sweat for disease diagnostics and health monitoring.

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Supplementary files

Publication details

The article was received on 30 Jan 2019, accepted on 12 Mar 2019 and first published on 12 Mar 2019


Article type: Paper
DOI: 10.1039/C9LC00103D
Citation: Lab Chip, 2019, Accepted Manuscript

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    Passive, non-pharmacological sweat collection and analysis using a skin-interfaced, soft microfluidic system with colorimetric biomarker assays relevant to kidney disorders

    Y. Zhang, H. Guo, S. B. Kim, Y. Wu, D. Ostojich, S. H. Park, X. Wang, R. Li, A. Bandodkar, Y. Sekine, Z. Weng, J. Choi, S. Xu, S. Quaggin, R. Ghaffari and J. A. Rogers, Lab Chip, 2019, Accepted Manuscript , DOI: 10.1039/C9LC00103D

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