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Issue 18, 2019
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Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

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Abstract

Enantioselective conversion of alcohols to ketones using air as the oxidant is achieved with high rates and efficiency using an indium tin oxide (ITO) electrode in which an alcohol dehydrogenase and a photosynthetic NADPH recycling enzyme are confined within nanopores. The massive catalytic enhancement arising from nanoconfinement is exploited in an air-driven electrochemical cell, which requires no complicating control features yet allows continuous monitoring of the reaction via the current that flows between anode (ITO: organic chemistry) and cathode (Pt: O2 from air).

Graphical abstract: Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

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Publication details

The article was received on 08 May 2019, accepted on 15 Jul 2019 and first published on 30 Aug 2019


Article type: Communication
DOI: 10.1039/C9GC01534E
Green Chem., 2019,21, 4958-4963
  • Open access: Creative Commons BY license
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    Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

    L. Wan, R. S. Heath, B. Siritanaratkul, C. F. Megarity, A. J. Sills, M. P. Thompson, N. J. Turner and F. A. Armstrong, Green Chem., 2019, 21, 4958
    DOI: 10.1039/C9GC01534E

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