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Issue 18, 2019
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Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

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Abstract

Enantioselective conversion of alcohols to ketones using air as the oxidant is achieved with high rates and efficiency using an indium tin oxide (ITO) electrode in which an alcohol dehydrogenase and a photosynthetic NADPH recycling enzyme are confined within nanopores. The massive catalytic enhancement arising from nanoconfinement is exploited in an air-driven electrochemical cell, which requires no complicating control features yet allows continuous monitoring of the reaction via the current that flows between anode (ITO: organic chemistry) and cathode (Pt: O2 from air).

Graphical abstract: Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

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Supplementary files

Article information


Submitted
08 May 2019
Accepted
15 Jul 2019
First published
30 Aug 2019

This article is Open Access

Green Chem., 2019,21, 4958-4963
Article type
Communication

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

L. Wan, R. S. Heath, B. Siritanaratkul, C. F. Megarity, A. J. Sills, M. P. Thompson, N. J. Turner and F. A. Armstrong, Green Chem., 2019, 21, 4958
DOI: 10.1039/C9GC01534E

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