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Issue 13, 2019
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Continuous manufacturing – the Green Chemistry promise?

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Abstract

Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles.

Graphical abstract: Continuous manufacturing – the Green Chemistry promise?

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Article information


Submitted
04 Mar 2019
Accepted
21 May 2019
First published
21 May 2019

This article is Open Access

Green Chem., 2019,21, 3481-3498
Article type
Critical Review

Continuous manufacturing – the Green Chemistry promise?

L. Rogers and K. F. Jensen, Green Chem., 2019, 21, 3481
DOI: 10.1039/C9GC00773C

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