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Issue 8, 2019
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Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories

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Abstract

Plants have had numerous biological, clinical, pharmaceutical and medicinal purposes for many years; however, their use as a general platform for preparation of desired pharmaceutical and biomedical compounds is relatively current. Secondary metabolites with remarkable and diverse biological functions are produced by medicinal plants. Significant advancements in nanosciences have enabled their various applications in the development of a new generation of drug molecules. Due to the application of toxic solvents and high energy consumption of conventional physical and chemical approaches, greener and eco-friendly methods are essential and vital. Plants can provide an outstanding alternative for the production of phytomaterials and biomaterials, and this review highlights the exogenous and endogenous syntheses of nanoparticles using living plants. Additionally, the plant nano-molecular farming of proteins including collagen, gelatin, elastin, recombinant anti-cancer monoclonal antibodies and recombinant anti-cancer vaccines is discussed.

Graphical abstract: Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories

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Publication details

The article was received on 28 Jan 2019, accepted on 05 Mar 2019 and first published on 06 Mar 2019


Article type: Tutorial Review
DOI: 10.1039/C9GC00335E
Green Chem., 2019,21, 1845-1865

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    Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories

    R. Mohammadinejad, A. Shavandi, D. S. Raie, J. Sangeetha, M. Soleimani, S. Shokrian Hajibehzad, D. Thangadurai, R. Hospet, J. O. Popoola, A. Arzani, M. A. Gómez-Lim, S. Iravani and R. S. Varma, Green Chem., 2019, 21, 1845
    DOI: 10.1039/C9GC00335E

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