Jump to main content
Jump to site search

Issue 5, 2019
Previous Article Next Article

Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

Author affiliations

Abstract

In the present study, we aimed to investigate the therapeutic mechanisms of carrot juice fermented with Lactobacillus rhamnosus GG (LGG) on type 2 diabetic mellitus (T2DM) based on the regulation of gut microbiota. Carrot juice fermented with LGG was enriched with free phenols, organic acids and short-chain fatty acids (SCFAs). Supplementation of carrot juice fermented with LGG (DFCL) could favorably regulate blood glucose, insulin, antioxidant capacity and morphology of the pancreas and kidney in the diabetic rats, accompanied by an increase of SCFAs in the cecum. Furthermore, high-throughput sequencing (HTS) analysis revealed that DFCL supplementation altered the composition of gut microbiota, showing increased relative abundances of functionally relevant enterotypes, such as Christensenellaceae_R-7_group, Oscillibacter, Ruminococcaceae_UCG-013, Lachnospiraceae_NK4A136_group and Akkermansia. In addition, Spearman's correlation analysis revealed that Desulfovibrio, Ruminococcaceae and Alloprevotella were closely correlated with biochemical biomarkers. Meanwhile, DFCL treatment regulated the expressions of genes involved in glucose metabolism at the mRNA and protein levels.

Graphical abstract: Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Mar 2019, accepted on 30 Apr 2019 and first published on 02 May 2019


Article type: Paper
DOI: 10.1039/C9FO00475K
Food Funct., 2019,10, 2935-2946

  •   Request permissions

    Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

    R. Hu, F. Zeng, L. Wu, X. Wan, Y. Chen, J. Zhang and B. Liu, Food Funct., 2019, 10, 2935
    DOI: 10.1039/C9FO00475K

Search articles by author

Spotlight

Advertisements