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Issue 2, 2019
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Identification and availability of peptides from lactoferrin in the gastrointestinal tract of mice

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Abstract

Lactoferrin is a protein with multifunctional bioactivities. However, limited studies have reported the digestion behavior of lactoferrin in mice. In the present study, the metabolic fate of lactoferrin in the gastrointestinal tract (GIT) of mice was investigated. The mice were orally administered 4 mg of lactoferrin. The contents in the stomach, duodenum, jejunum and ileum were collected at 0.5 h, 1 h, 2 h and 3 h after administration. The peptides in the contents of the stomach, duodenum, jejunum and ileum were identified by electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) coupled with capillary electrophoresis (CE). At 0.5 h after administration, 350, 47, 118 and 26 novel peptides were identified in the contents of the stomach, duodenum, jejunum and ileum, respectively. At 1 h after administration, 175, 23, 3 and 8 novel peptides were identified in the contents of the stomach, duodenum, jejunum and ileum, respectively. At 2 h and 3 h after administration, 96 and 2 novel peptides were identified in the contents of the stomach, respectively. Among these peptides, 10 peptides were generated from gastrointestinal digestions and could play physiological roles when they are absorbed through the intestine in their original form. This work provided some theoretical basis for clarifying the bioactive mechanisms of lactoferrin.

Graphical abstract: Identification and availability of peptides from lactoferrin in the gastrointestinal tract of mice

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Publication details

The article was received on 13 Oct 2018, accepted on 14 Jan 2019 and first published on 17 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO01998C
Food Funct., 2019,10, 879-885

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    Identification and availability of peptides from lactoferrin in the gastrointestinal tract of mice

    F. Fan, P. Shi, H. Chen, M. Tu, Z. Wang, W. Lu and M. Du, Food Funct., 2019, 10, 879
    DOI: 10.1039/C8FO01998C

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