Jump to main content
Jump to site search

Issue 4, 2019
Previous Article Next Article

Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model

Author affiliations

Abstract

Rotavirus (RV) is a pathogen that induces severe diarrhea in infants and young animals. Shiitake mushroom is a traditional food, which can improve physiological function, including gut health. Lentinan (LNT) is the main functional component of Shiitake mushroom. This study aimed to verify whether LNT administration could improve intestinal barrier function, thereby decreasing RV-induced diarrhea in a porcine model. According to initial weight and origin, a total of 28 weaned piglets were randomly fed 2 diets containing 0 or 84 mg kg−1 LNT for 19 d (n = 14). On day 15, RV was orally infused to half of the pigs in each group. RV-induced diarrhea (P < 0.05), the positive rate of RV non-structural protein 4 (NSP4), impaired intestinal morphology, antioxidant capacity and microbiota (P < 0.05), and increased apoptosis of jejunal epithelial cells (P < 0.05) were assessed in the piglets. Dietary LNT supplementation was found to improve intestinal morphology, permeability, antioxidant capacity and microbiota (P < 0.05). Supplementation also further alleviated the effects of RV infection on diarrhea, intestinal morphology, permeability, antioxidant capacity, microbiota and apoptosis of jejunal epithelial cells in piglets (P < 0.05). Thus, these results suggest that LNT administration relieved RV-induced diarrhea in piglets, which could be due to the increase in antioxidant capacity, reduction in apoptosis and improvement of the microbiota-increased gut barrier.

Graphical abstract: Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Sep 2018, accepted on 11 Mar 2019 and first published on 14 Mar 2019


Article type: Paper
DOI: 10.1039/C8FO01764F
Food Funct., 2019,10, 2094-2101

  •   Request permissions

    Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model

    X. Mao, H. Hu, X. Xiao, D. Chen, B. Yu, J. He, J. Yu, P. Zheng, J. Luo, Y. Luo and J. Wang, Food Funct., 2019, 10, 2094
    DOI: 10.1039/C8FO01764F

Search articles by author

Spotlight

Advertisements